Global analysis of the Staphylococcus aureus response to mupirocin.

Abstract

In the present study, we analyzed the response of S. aureus to mupirocin, the drug of choice for nasal decolonization. Mupirocin selectively inhibits the bacterial isoleucyl-tRNA synthetase (IleRS), leading to the accumulation of uncharged isoleucyl-tRNA and eventually the synthesis of (p)ppGpp. The alarmone (p)ppGpp induces the stringent response, an… (More)
DOI: 10.1128/AAC.05363-11

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Cite this paper

@article{Reiss2012GlobalAO, title={Global analysis of the Staphylococcus aureus response to mupirocin.}, author={Swantje Reiss and Jan Pan{\'e}-Farr{\'e} and S. Fuchs and Patrice François and Manuel Liebeke and Jacques Schrenzel and Ulrike Lindequist and Michael Lalk and Christiane Wolz and Michael Hecker and S. Engelmann}, journal={Antimicrobial agents and chemotherapy}, year={2012}, volume={56 2}, pages={787-804} }