Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates

@article{Passegu2005GlobalAO,
  title={Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates},
  author={Emmanuelle Passegu{\'e} and Amy J. Wagers and Sylvie Giuriato and Wade C. Anderson and Irving L Weissman},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={202},
  pages={1599 - 1611}
}
Knowledge of the molecular networks controlling the proliferation and fate of hematopoietic stem cells (HSC) is essential to understand their function in maintaining blood cell production during normal hematopoiesis and upon clinical transplantation. Using highly purified stem and progenitor cell populations, we define the proliferation index and status of the cell cycle machinery at discrete stages of hematopoietic differentiation and during cytokine-mediated HSC mobilization. We identify… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

9 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Blood CellsAnatomy originated from biological processHematopoiesis
Knowledge of the molecular networks controlling the proliferation and fate of hematopoietic stem cells ( HSC ) is essential to understand their function in maintaining blood cell production during normal hematopoiesis and upon clinical transplantation .
Knowledge of the molecular networks controlling the proliferation and fate of hematopoietic stem cells ( HSC ) is essential to understand their function in maintaining blood cell production during normal hematopoiesis and upon clinical transplantation .
Knowledge of the molecular networks controlling the proliferation and fate of hematopoietic stem cells ( HSC ) is essential to understand their function in maintaining blood cell production during normal hematopoiesis and upon clinical transplantation .
All Topics