Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation

@inproceedings{Grober2010GlobalAO,
  title={Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation},
  author={Oli M V Grober and Margherita Mutarelli and Giorgio Giurato and Maria Ravo and Luigi Cicatiello and Maria Rosaria De Filippo and Lorenzo Ferraro and Giovanni Nassa and Maria Francesca Papa and Ornella Paris and Roberta Tarallo and Shujun Luo and Gary P. Schroth and Vladimir Benes and Alessandro Weisz},
  booktitle={BMC Genomics},
  year={2010}
}
Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors (TFs) that mediate estrogen signaling and define the hormone-responsive phenotype of breast cancer (BC). The two receptors can be found co-expressed and play specific, often opposite, roles, with ERβ being able to modulate the effects of ERα on gene transcription and cell proliferation. ERβ is frequently lost in BC, where its presence generally correlates with a better prognosis of the disease. The identification of the… CONTINUE READING