Global analysis of alternative splicing during T-cell activation.

  title={Global analysis of alternative splicing during T-cell activation.},
  author={Joanna Y Y Ip and Alan Tong and Qun Pan and Justin D Topp and Benjamin J. Blencowe and Kristen W. Lynch},
  volume={13 4},
The role of alternative splicing (AS) in eliciting immune responses is poorly understood. We used quantitative AS microarray profiling to survey changes in AS during activation of Jurkat cells, a leukemia-derived T-cell line. Our results indicate that approximately 10-15% of the profiled alternative exons undergo a >10% change in inclusion level during activation. The majority of the genes displaying differential AS levels are distinct from the set of genes displaying differential transcript… CONTINUE READING

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