Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury.

@article{Lin2005GlobalAO,
  title={Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury.},
  author={Amy H.-M. Lin and Jian Luo and Lauren H Mondshein and Peter Ten Dijke and Denis Vivien and Christopher H. Contag and Tony Wyss-Coray},
  journal={Journal of immunology},
  year={2005},
  volume={175 1},
  pages={547-54}
}
Smad2 and Smad3 (Smad2/3) proteins are key signaling molecules for TGF-beta and some related family members regulating the transcription of several hundred genes. TGF-beta have key roles in development, tissue homeostasis, and the pathogenesis of many human diseases, including cancer, fibrotic disorders, developmental defects, and neurodegeneration. To study the temporal and spatial patterns of Smad2/3-dependent signaling in normal and pathological conditions in the living organism, we… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
32 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 32 extracted citations

Similar Papers

Loading similar papers…