Global analysis of Plasmodium falciparum Na(+)/H(+) exchanger (pfnhe-1) allele polymorphism and its usefulness as a marker of in vitro resistance to quinine.

@article{Mnard2013GlobalAO,
  title={Global analysis of Plasmodium falciparum Na(+)/H(+) exchanger (pfnhe-1) allele polymorphism and its usefulness as a marker of in vitro resistance to quinine.},
  author={Didier M{\'e}nard and Val{\'e}rie Andriantsoanirina and Nimol Khim and Ars{\`e}ne C Ratsimbasoa and Beno{\^i}t Witkowski and Christophe Benedet and Lydie Canier and Odile Mercereau-Puijalon and R{\'e}my Durand},
  journal={International journal for parasitology. Drugs and drug resistance},
  year={2013},
  volume={3},
  pages={8-19}
}
The aim of this study was to provide a comprehensive analysis of the worldwide genetic polymorphism of ms4760 alleles of the pfnhe-1 gene and to discuss their usefulness as molecular marker of quinine resistance (QNR). A new numbering of ms4760 allele, classification grouping ms4760 alleles according to the number of DNNND and DDNHNDNHNND repeat motifs in blocks II and V was also proposed. A total of 1508 ms4760 sequences from isolates, culture-adapted parasites or reference strains from… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-6 of 6 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 58 references

FSTAT (Version 1.2): a computer program to calculate F-statistics

  • J. Goudet
  • J. Hered.,
  • 1995
Highly Influential
2 Excerpts

Similar Papers

Loading similar papers…