Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression

@article{Ngollo2017GlobalAO,
  title={Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression},
  author={Marjolaine Ngollo and Andr{\'e} Lebert and Marine Daures and Ga{\"e}lle Judes and Khaldoun T Rifai and Lucas Dubois and Jean Louis K{\'e}m{\'e}ny and Fr{\'e}d{\'e}rique Penault-Llorca and Yves-Jean Bignon and Laurent Guy and Dominique J. BERNARD-GALLON},
  journal={BMC Cancer},
  year={2017},
  volume={17}
}
BackgroundH3K27me3 histone marks shape the inhibition of gene transcription. In prostate cancer, the deregulation of H3K27me3 marks might play a role in prostate tumor progression.MethodsWe investigated genome-wide H3K27me3 histone methylation profile using chromatin immunoprecipitation (ChIP) and 2X400K promoter microarrays to identify differentially-enriched regions in biopsy samples from prostate cancer patients. H3K27me3 marks were assessed in 34 prostate tumors: 11 with Gleason score > 7… Expand
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