Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.

@article{Grundberg2013GlobalAO,
  title={Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.},
  author={Elin Grundberg and Eshwar Meduri and Johanna K. Sandling and Asa K. Hedman and Sarah Keildson and Alfonso Buil and Stephan Busche and Wei Yuan and James Nisbet and Magdalena Sekowska and Alicja E Wilk and Amy Barrett and Kerrin S. Small and Bing Ge and Maxime Caron and So-Youn Shin and Mark Lathrop and Emmanouil T. Dermitzakis and Mark I. McCarthy and Tim D. Spector and Jordana T. Bell and Panagiotis Deloukas},
  journal={American journal of human genetics},
  year={2013},
  volume={93 5},
  pages={876-90}
}
Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. However, little is known about the genome-wide frequency, localization, and function of methylation variation and how it is regulated by genetic and environmental factors. We utilized the Multiple Tissue Human Expression Resource (MuTHER) and generated Illumina 450K adipose methylome data from 648 twins. We found that individual CpGs had low variance and that variability was… CONTINUE READING
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The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue

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