Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

@inproceedings{Metcalf2015GlobalAR,
  title={Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors},
  author={Talibah U. Metcalf and Rafael Cubas and Khader Ghneim and Michael J Cartwright and Julien van Grevenynghe and Justin M Richner and David P Olagnier and Peter A Wilkinson and Mark J Cameron and Byung S Park and John Hiscott and Michael S Diamond and Anne M Wertheimer and Janko Nikolich-Žugich and Elias K Haddad},
  booktitle={Aging cell},
  year={2015}
}
Aging leads to dysregulation of multiple components of the immune system that results in increased susceptibility to infections and poor response to vaccines in the aging population. The dysfunctions of adaptive B and T cells are well documented, but the effect of aging on innate immunity remains incompletely understood. Using a heterogeneous population of peripheral blood mononuclear cells (PBMCs), we first undertook transcriptional profiling and found that PBMCs isolated from old individuals… CONTINUE READING
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