Global View on Ant Venom Allergy: from Allergenic Components to Clinical Management

  title={Global View on Ant Venom Allergy: from Allergenic Components to Clinical Management},
  author={Troy Wanandy and Emily M Mulcahy and Wun Yee Lau and Simon G. A. Brown and Michael D. Wiese},
  journal={Clinical Reviews in Allergy \& Immunology},
Hymenoptera venom allergy is characterised by systemic anaphylactic reactions that occur in response to stings from members of the Hymenoptera order. Stinging by social Hymenoptera such as ants, honeybees, and vespids is one of the 3 major causes of anaphylaxis; along with food and drug exposure, it accounts for up to 43% of anaphylaxis cases and 20% of anaphylaxis-related fatalities. Despite their recognition as being of considerable public health significance, stinging ant venoms are… 
1 Citations

Ant sting-induced whole-body pustules in an inebriated male: A case report

A 70-year-old man was bitten by a large number of ants when he was in a drunken stupor and was hospitalized at a local hospital, where he was diagnosed with an ant venom allergy.



Insect venoms.

  • U. Müller
  • Biology, Medicine
    Chemical immunology and allergy
  • 2010
Allergen-specific immunotherapy with Hymanoptera venoms is highly effective and therefore recommended for all patients with a history of Hymenoptera sting anaphylaxis and positive diagnostic tests with the respective venom.

EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy

This guideline aims to provide evidence‐based recommendations for the use of venom immunotherapy, has been informed by a formal systematic review and meta‐analysis and produced using the Appraisal of Guidelines for Research and Evaluation (AGREE II) approach.

Prevention of anaphylaxis with ant venom immunotherapy

  • S. BrownR. Heddle
  • Medicine, Biology
    Current opinion in allergy and clinical immunology
  • 2003
Ant venom immunotherapy is feasible and highly efficacious, however, the limited geographical distribution of each species presents a major challenge to making venom extracts available for clinical use.

Allergen-specific immunotherapy of Hymenoptera venom allergy – also a matter of diagnosis

During the last decade the detailed knowledge of the allergen composition of hymenoptera venoms has substantially improved diagnosis and therapy of venom allergy, as well as on novel directions trying to improve therapy.

The natural history and epidemiology of insect venom allergy: clinical implications

  • M. BilòF. Bonifazi
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2009
At least half of the sting fatalities in patients with a positive history could have been avoided through the timely administration of specific immunotherapy, indicating the urgent need to educate the general population and doctors on the management of venom‐allergic patients.

Hymenoptera venom proteins and peptides for diagnosis and treatment of venom allergic patients.

Immunotherapy with Hymenoptera venoms has been shown to protect 80 to over 95% of patients with a history of systemic allergic sting reaction from further systemic reactions after re-stings, and the procedure, safety and efficacy of this treatment and the immune mechanisms involved are discussed.

Epidemiology of insect-venom anaphylaxis

The epidemiological studies on sting anaphylaxis conducted in the 2000s continue to reveal the poor management of allergic patients and the startling lack of awareness of the efficacy of venom immunotherapy, indicating the urgent need to educate the general population and doctors on the management of venom-allergic patients.

Ant allergens and hypersensitivity reactions in response to ant stings.

Management of ant hypersensitivity can be divided into immediate (epinephrine, corticosteroids), symptomatic (antihistamines, bronchodilators), supportive (fluid resuscitation, oxygen therapy), and preventive (re-sting avoidance and immunotherapy) treatments.

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Fire ant diagnostics seem appropriate to use in determining sensitisation to mound-building wood ants in patients with severe fire ant-venom allergy, whereas in patients presenting with minor allergic reactions, e.g. after bites by mound- Building wood ants, the recommend desensitisation by immunotherapy.