Global Varicella Vaccine Effectiveness: A Meta-analysis

@article{Marin2016GlobalVV,
  title={Global Varicella Vaccine Effectiveness: A Meta-analysis},
  author={Mona Marin and Melanie Marti and Anita K. Kambhampati and Stanley M. Jeram and Jane F. Seward},
  journal={Pediatrics},
  year={2016},
  volume={137}
}
CONTEXT Several varicella vaccines are available worldwide. [...] Key MethodDATA SOURCES Systematic review and descriptive and meta-analysis of Medline, Embase, Cochrane libraries, and CINAHL databases for reports published during 1995-2014. STUDY SELECTION Publications that reported original data on dose-specific varicella VE among immunocompetent children. Expand
Systematic review of effectiveness of varicella vaccines: A critical appraisal
TLDR
One dose of varicella vaccine was moderately effective in preventing allvaricella, and highly effective in prevents moderate/ severe varicellas, with no differences by vaccine. Expand
Two-dose varicella vaccine effectiveness in China: a meta-analysis and evidence quality assessment
TLDR
The VE of two-dose varicella vaccine is relatively high in preventingvaricella, and is recommended for countries which need further control for variceella, however, higher quality evidence is needed as a supplement for stronger recommendations. Expand
Effectiveness, immunogenicity and safety of one vs. two-dose varicella vaccination:a meta-analysis
TLDR
Two-dose varicella vaccination resulted in higher levels of immunogenicity and provided superior protection than 1-dose vaccination, and safety profiles showed 2- dose vaccination was well tolerated but the incidence of grade 3 redness and of any intensity was significantly higher. Expand
Transmission of Vaccine-Strain Varicella-Zoster Virus: A Systematic Review
TLDR
Healthy, vaccinated persons have minimal risk for transmitting vOka to contacts and only if a rash is present, and the existing recommendations for routine varicella vaccination and the guidance that persons with vaccine-related rash avoid contact with susceptible persons at high risk for severevaricella complications are supported. Expand
Modeling Cost-Effectiveness of Universal Varicella Vaccination With Different Varicella Vaccines in the United Kingdom
TLDR
The use of predicted efficacy inputs for 1-dose V-MSD may not accurately reflect the actual vaccine performance and cost-effectiveness, considering availability of observed efficacy and effectiveness data. Expand
Varicella vaccination - the global experience
TLDR
There is currently no evidence to suggest that the introduction of varicella vaccination results in a shift ofvaricella disease burden to older age groups, and it is likely that this secular trend was evident before their introduction. Expand
Varicella vaccine effectiveness over 10 years in Australia; moderate protection from 1-dose program.
TLDR
Greater reductions in varicella disease could potentially be achieved by incorporation of a second vaccine dose into the program to minimise breakthrough disease and interrupt virus circulation. Expand
Incidence rate of breakthrough varicella observed in healthy children after 1 or 2 doses of varicella vaccine: Results from a meta‐analysis
TLDR
Two doses of varicella vaccine are more effective than a single dose, and 3‐4 years between the first and second vaccinations may achieve higher efficacy. Expand
Health Impact and Cost-effectiveness Assessment for the Introduction of Universal Varicella Vaccination in Switzerland
TLDR
Universal varicella vaccination appears highly effective and cost-effective when compared with current clinical practice and recommendations in Switzerland from both a direct medical costs perspective and societal perspective. Expand
Effectiveness of second-dose varicella vaccination as post-exposure prophylaxis: a prospective cohort study.
  • Q. Wu, J. Liu, +7 authors Y. Hu
  • Medicine
  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2019
TLDR
Assessment of the vaccine effectiveness of 2nd-dose VarV as PEP among students involved in 129 varicella outbreaks in Shanghai, China from 2013 to 2016 suggests that administration of 2 second dose VarVAs PEP is an appropriate intervention for outbreak control in countries where two-doseVarV has not been adopted. Expand
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Metaanalysis of vaccine effectiveness in varicella outbreaks.
TLDR
A metaanalysis confirms a limited effectiveness of one dose of varicella vaccine and points to waning immunity as an important causal factor, which might also be an issue with the newly recommended two dose vaccination schedule. Expand
Two-dose Varicella Vaccine Effectiveness and Rash Severity in Outbreaks of Varicella Among Public School Students
TLDR
Two-dose varicella vaccination is highly effective and confers higher protection than a 1-dose regimen, and high 2- overdose vaccination coverage should maximize the benefits of the variceella vaccination program and further reducevaricella disease burden in the United States. Expand
Impact of a Routine Two-Dose Varicella Vaccination Program on Varicella Epidemiology
TLDR
Declines in incidence across all ages, including infants who are not eligible for varicella vaccination, and adults, in whom vaccination levels are low, provide evidence of the benefit of high levels of immunity in the population. Expand
The Effectiveness of Varicella Vaccination in Children in Germany: A Case-control Study
TLDR
One dose ofvaricella vaccine provided high protection against moderate and severe varicella disease for a period of up to 5 years after vaccination, however, further effectiveness data are needed to assess long-term protection. Expand
Impact of the routine varicella vaccination programme on varicella epidemiology in Germany.
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TLDR
It is confirmed that following the introduction of routine varicella vaccination,varicella morbidity started to decline in Germany andVaricella cases started to decrease early as well. Expand
Challenges in confirming a varicella outbreak in the two-dose vaccine era.
TLDR
Clinical and epidemiologic data suggests varicella as the likely cause of a suspected variceella outbreak in School District X, Texas, and better diagnostics are needed for diagnosis ofvaricella in vaccinated individuals so that appropriate outbreak control measures can be implemented. Expand
Single-dose varicella vaccine effectiveness in school settings in China.
TLDR
Single-dose varicella vaccine is highly effective in school settings, and maintaining limited vaccination coverage might shift variceella disease burden to older individuals, who are more prone to develop severe outcomes ifvaricella occurs. Expand
Younger age at vaccination may increase risk of varicella vaccine failure.
TLDR
A varicella outbreak in a highly vaccinated day-care center (DCC) population in Pennsylvania was investigated, and vaccination at early age at vaccination may increase the risk of vaccine failure. Expand
Comparative varicella vaccine effectiveness during outbreaks in day-care centres.
TLDR
Enhanced efforts to increase VC in Germany and 2 doses varicella vaccine might be successful to reduce the risk for BV, and the evidence that VE and risk of BV are associated with vaccine brand needs further investigation. Expand
One Dose of Varicella Vaccine Does Not Prevent School Outbreaks: Is it Time for a Second Dose?
TLDR
Although disease was mostly mild, the outbreak lasted for ∼2 months, suggesting that varicella in vaccinated persons was contagious and that 99%varicella vaccination coverage was not sufficient to prevent the outbreak, this investigation highlights several challenges related to the prevention and control of variceLLA outbreaks. Expand
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