Global Suppression of IL-6-induced Acute Phase Response Gene Expression after Chronic in Vivo Treatment with the Peroxisome Proliferator-activated Receptor-α Activator Fenofibrate*

@article{Gervois2004GlobalSO,
  title={Global Suppression of IL-6-induced Acute Phase Response Gene Expression after Chronic in Vivo Treatment with the Peroxisome Proliferator-activated Receptor-$\alpha$ Activator Fenofibrate*},
  author={P. Gervois and R. Kleemann and A. Pilon and F. Percevault and W. Koenig and B. Staels and T. Kooistra},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={16154 - 16160}
}
The peroxisome proliferator-activated receptor α (PPARα), which is highly expressed in liver, plays key roles in lipid metabolism and inflammation. Interleukin-6 (IL-6) is the principal inducer of acute phase response (APR) gene expression. In the present study, we demonstrate that chronic treatment with the PPARα agonist fenofibrate fully prevents the IL-6-induced APR gene expression in wild-type but not in PPARα-deficient mice. PPARα prevents the IL-6-induced expression of the positive APR… Expand
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