Global SUMOylation on active chromatin is an acute heat stress response restricting transcription

  title={Global SUMOylation on active chromatin is an acute heat stress response restricting transcription},
  author={Einari A. Niskanen and Marjo Malinen and P{\"a}ivi Sutinen and Sari Toropainen and Ville Paakinaho and Anniina Vihervaara and Jenny Joutsen and Minna U Kaikkonen and Lea Sistonen and Jorma J. Palvimo},
  booktitle={Genome Biology},
Cells have developed many ways to cope with external stress. One distinctive feature in acute proteotoxic stresses, such as heat shock (HS), is rapid post-translational modification of proteins by SUMOs (small ubiquitin-like modifier proteins; SUMOylation). While many of the SUMO targets are chromatin proteins, there is scarce information on chromatin binding of SUMOylated proteins in HS and the role of chromatin SUMOylation in the regulation of transcription. We mapped HS-induced genome-wide… CONTINUE READING
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