Global Regulation of H2A.Z Localization by the INO80 Chromatin-Remodeling Enzyme Is Essential for Genome Integrity

@article{PapamichosChronakis2011GlobalRO,
  title={Global Regulation of H2A.Z Localization by the INO80 Chromatin-Remodeling Enzyme Is Essential for Genome Integrity},
  author={Manolis Papamichos-Chronakis and Shinya Watanabe and Oliver J Rando and Craig L. Peterson},
  journal={Cell},
  year={2011},
  volume={144},
  pages={200-213}
}
INO80 is an evolutionarily conserved, ATP-dependent chromatin-remodeling enzyme that plays roles in transcription, DNA repair, and replication. Here, we show that yeast INO80 facilitates these diverse processes at least in part by controlling genome-wide distribution of the histone variant H2A.Z. In the absence of INO80, H2A.Z nucleosomes are mislocalized, and H2A.Z levels at promoters show reduced responsiveness to transcriptional changes, suggesting that INO80 controls H2A.Z dynamics… CONTINUE READING
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The Saccharomyces cerevisiae histone H 2 A variant Htz 1 is acetylated by NuA 4

  • M. C. Keogh, T. A. Mennella, +7 authors K. Baetz
  • Genes Dev .
  • 2006
Highly Influential
4 Excerpts

A protein complex containing the conserved Swi 2 / Snf 2 - related ATPase Swr 1 p deposits histone variant H 2 A . Z into euchromatin

  • M. S. Kobor, S. Venkatasubrahmanyam, +4 authors J. Rine
  • PLoS Biol .
  • 2004
Highly Influential
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