Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent

Abstract

Prostate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five times that among African Americans and is expected to double in Africa by 2030. We summarize publicly available CaP data and collected data from the men of African descent and Carcinoma of the Prostate (MADCaP) Consortium and the African Caribbean Cancer Consortium (AC3) to evaluate CaP incidence and mortality in men of African descent worldwide. CaP incidence and mortality are highest in men of African descent in the USA and the Caribbean. Tumor stage and grade were highest in SSA. We report a higher proportion of T1 stage prostate tumors in countries with greater percent gross domestic product spent on health care and physicians per 100,000 persons. We also observed that regions with a higher proportion of advanced tumors reported lower mortality rates. This finding suggests that CaP is underdiagnosed and/or underreported in SSA men. Nonetheless, CaP incidence and mortality represent a significant public health problem in men of African descent around the world.

DOI: 10.1155/2013/560857

Extracted Key Phrases

5 Figures and Tables

010020020132014201520162017
Citations per Year

457 Citations

Semantic Scholar estimates that this publication has 457 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@inproceedings{Rebbeck2013GlobalPO, title={Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent}, author={Timothy R. Rebbeck and Susan S. Devesa and Bao-li Chang and Clareann H. Bunker and Iona Cheng and Kathleen A Cooney and Rosalind A Eeles and Pedro Fern{\'a}ndez and Veda Nargund Giri and Serigne Gueye and Christopher A. Haiman and Brian E. Henderson and Chris F. Heyns and Jennifer J. Hu and Sue Ann Ingles and Williams B. Isaacs and Mohamed Jalloh and Esther M. John and Adam S. Kibel and La Creis Kidd and Penelope J Layne and Robin J. Leach and Christine M Neslund-Dudas and Michael N. Okobia and Elaine A. Ostrander and Jong Y. Park and Alan Leslie Patrick and Catherine M. Phelan and Camille C Rose Ragin and Robin Roberts and Benjamin A Rybicki and Janet L. Stanford and Sara S . Strom and Ian M. Thompson and John S. Witte and Jianfeng Xu and Edward Donkoh Yeboah and Ann W. Hsing and Charnita M. Zeigler-Johnson}, booktitle={Prostate cancer}, year={2013} }