Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins

@article{Tishkoff1996GlobalPO,
  title={Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins},
  author={Sarah A. Tishkoff and E. Dietzsch and W C Speed and Andrew J. Pakstis and Judith R. Kidd and K H Cheung and Batsheva Bonn{\'e}‐Tamir and A. Silvana Santachiara‐Benerecetti and Pedro Moral and Matthias Krings and Svante P{\"a}{\"a}bo and E. M. Watson and Neil Risch and Trefor Jenkins and Kenneth K. Kidd},
  journal={Science},
  year={1996},
  volume={271},
  pages={1380 - 1387}
}
Key MethodHaplotypes consisting of alleles at a short tandem repeat polymorphism (STRP) and an Alu deletion polymorphism at the CD4 locus on chromosome 12 were analyzed in more than 1600 individuals sampled from 42 geographically dispersed populations (13 African, 2 Middle Eastern, 7 European, 9 Asian, 3 Pacific, and 8 Amerindian). Sub-Saharan African populations had more haplotypes and exhibited more variability in frequencies of haplotypes than the Northeast African or non-African populations. The Alu…
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