Global Occurrence of Infant Botulism, 1976–2006

@article{Koepke2008GlobalOO,
  title={Global Occurrence of Infant Botulism, 1976–2006},
  author={Robert Louis Koepke and Jeremy Sobel and Stephen S. Arnon},
  journal={Pediatrics},
  year={2008},
  volume={122},
  pages={e73 - e82}
}
OBJECTIVE. To summarize the worldwide occurrence of reported infant (intestinal toxemia) botulism cases since first recognition of the disease in 1976. PATIENTS AND METHODS. We collected information on infant botulism cases by active and passive surveillance, by provision of therapeutic Human Botulism Immune Globulin to suspected cases, and by searching the medical literature. We defined a case as laboratory-confirmed botulism that occurred in an infant ≤12 months of age that was not caused by… Expand

Paper Mentions

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Clinical suspicion of infant botulism, which is a treatable infantile neuromuscular disease, is essential for early diagnosis and prompt treatment in the differential diagnosis of a floppy infant. Expand
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Over the 23 years 1992‐2015, patients presenting with illnesses so clinically similar to infant botulism that they were treated with BIG‐IV had actual diagnoses that were distributed into 5 main categories that constitute a working bedside differential diagnosis of infantBotulism. Expand
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TLDR
A readable synthesis of the best current literature on microbiological, epidemiological and clinical features of infant botulism is provided, and a practical guide for its treatment is provided. Expand
Infant botulism in Costa Rica: first report from Central America.
TLDR
Although infant botulism is a known disease, the limitations in identifying it in Central America contributes to the misdiagnosis and under-reporting of this disease. Expand
Tetanus, Botulism, and Diphtheria
TLDR
Tetanus, botulism, and diphtheric neuropathy are rare in higher-resource settings where most neurologists practice; however, familiarity with the unique clinical manifestations and laboratory evaluation for these disorders is essential for the rapid diagnosis and treatment of patients with these conditions. Expand
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