Global N-acetylaspartate declines even in benign multiple sclerosis.

@article{Rigotti2011GlobalND,
  title={Global N-acetylaspartate declines even in benign multiple sclerosis.},
  author={Daniel J Rigotti and Oded Gonen and Robert I. Grossman and James S. Babb and Andrea Falini and Brett Benedetti and Massimo Filippi},
  journal={AJNR. American journal of neuroradiology},
  year={2011},
  volume={32 1},
  pages={204-9}
}
BACKGROUND AND PURPOSE Neuro-axonal damage is a well known sequelae of MS pathogeneses. Consequently, our aim was to test whether the ∼20% of patients with MS exhibiting a clinically benign disease course also have minimal neural dysfunction as reflected by the global concentration of their MR imaging marker NAA. MATERIALS AND METHODS Q(NAA) was obtained with nonlocalizing whole-head (1)H-MR spectroscopy in 43 patients with benign RRMS (30 women, 13 men; mean age, 44.7 ± 7.3 years of age… CONTINUE READING

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Axonal injury and disability

  • DL Arnold, N De Stefano, S Narayanan
  • Rigotti AJNR
  • 2011
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