Global Mapping of the Yeast Genetic Interaction Network

@article{Tong2004GlobalMO,
  title={Global Mapping of the Yeast Genetic Interaction Network},
  author={A. Tong and G. Lesage and Gary D Bader and Huiming Ding and H. Xu and Xiaofeng Xin and James Young and G. Berriz and Ren{\'e}e L. Brost and Michael Chang and Yiqun Chen and X. Cheng and G. Chua and H. Friesen and D. Goldberg and J. Haynes and Christine Humphries and Grace He and Shamiza Hussein and Lizhu Ke and N. Krogan and Zhijian Li and J. Levinson and Hong Lu and P. M{\'e}nard and Christella Munyana and A. Parsons and Owen W. Ryan and Raffi Tonikian and T. Roberts and A. Sdicu and Jesse Shapiro and Bilal Sheikh and B. Suter and S. L. Wong and Lan V. Zhang and Hongwei Zhu and C. Burd and S. Munro and C. Sander and J. Rine and J. Greenblatt and M. Peter and A. Bretscher and G. Bell and F. P. Roth and G. Brown and B. Andrews and H. Bussey and Charles Boone},
  journal={Science},
  year={2004},
  volume={303},
  pages={808 - 813}
}
A genetic interaction network containing ∼1000 genes and ∼4000 interactions was mapped by crossing mutations in 132 different query genes into a set of ∼4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local… Expand

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