Global Mapping of the Yeast Genetic Interaction Network

  title={Global Mapping of the Yeast Genetic Interaction Network},
  author={A. Tong and G. Lesage and G. Bader and H. Ding and H. Xu and X. Xin and J. Young and G. Berriz and Ren{\'e}e L. Brost and Michael Chang and Y. Chen and Xin Cheng and G. Chua and H. Friesen and D. S. Goldberg and J. Haynes and Christine Humphries and Grace He and S. Hussein and Lizhu Ke and N. Krogan and Z. Li and Joshua N. Levinson and H. Lu and P. M{\'e}nard and Christella Munyana and A. Parsons and Owen W. Ryan and Raffi Tonikian and T. Roberts and Anne-Marie Sdicu and J. Shapiro and B. Sheikh and B. Suter and S. L. Wong and Lan V. Zhang and Hongwei Zhu and C. Burd and S. Munro and C. Sander and J. Rine and J. Greenblatt and M. Peter and A. Bretscher and G. Bell and F. Roth and G. Brown and B. Andrews and H. Bussey and C. Boone},
  pages={808 - 813}
  • A. Tong, G. Lesage, +47 authors C. Boone
  • Published 2004
  • Medicine, Biology
  • Science
  • A genetic interaction network containing ∼1000 genes and ∼4000 interactions was mapped by crossing mutations in 132 different query genes into a set of ∼4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local… CONTINUE READING

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