Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection.

  title={Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection.},
  author={Kathleen M. Mirrashidi and Cherilyn A Elwell and Erik Verschueren and Jeffrey R. Johnson and Andrew Frando and John von Dollen and Oren S Rosenberg and Natali Gulbahce and Gwendolyn M. Jang and Tasha Johnson and Stefanie J{\"a}ger and Anusha M. Gopalakrishnan and Jessica Sherry and Joe Dan Dunn and Andrew J Olive and Bennett H. Penn and Michael Shales and J. Stan Cox and Michael N. Starnbach and Isabelle Derr{\'e} and Raphael H. Valdivia and Nevan J. Krogan and Joanne N. Engel},
  journal={Cell host & microbe},
  volume={18 1},
Chlamydia trachomatis is a leading cause of genital and ocular infections for which no vaccine exists. Upon entry into host cells, C. trachomatis resides within a membrane-bound compartment—the inclusion—and secretes inclusion membrane proteins (Incs) that are thought to modulate the host-bacterium interface. To expand our understanding of Inc function(s), we subjected putative C. trachomatis Incs to affinity purification-mass spectroscopy (AP-MS). We identified Inc-human interactions for 38/58… CONTINUE READING
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