Global Mapping of Human RNA-RNA Interactions.

  title={Global Mapping of Human RNA-RNA Interactions.},
  author={Eesha Sharma and Tim Sterne-Weiler and Dave O'Hanlon and Benjamin J. Blencowe},
  journal={Molecular cell},
  volume={62 4},
The majority of the human genome is transcribed into non-coding (nc)RNAs that lack known biological functions or else are only partially characterized. Numerous characterized ncRNAs function via base pairing with target RNA sequences to direct their biological activities, which include critical roles in RNA processing, modification, turnover, and translation. To define roles for ncRNAs, we have developed a method enabling the global-scale mapping of RNA-RNA duplexes crosslinked in vivo… CONTINUE READING