Global Identification of Human Transcribed Sequences with Genome Tiling Arrays

@article{Bertone2004GlobalIO,
  title={Global Identification of Human Transcribed Sequences with Genome Tiling Arrays},
  author={Paul Bertone and V. {\vS}tolc and Thomas E. Royce and J. Rozowsky and A. Urban and X. Zhu and John L. Rinn and W. Tongprasit and Manoj Samanta and S. Weissman and M. Gerstein and M. Snyder},
  journal={Science},
  year={2004},
  volume={306},
  pages={2242 - 2246}
}
  • Paul Bertone, V. Štolc, +9 authors M. Snyder
  • Published 2004
  • Biology, Medicine
  • Science
  • Elucidating the transcribed regions of the genome constitutes a fundamental aspect of human biology, yet this remains an outstanding problem. To comprehensively identify coding sequences, we constructed a series of high-density oligonucleotide tiling arrays representing sense and antisense strands of the entire nonrepetitive sequence of the human genome. Transcribed sequences were located across the genome via hybridization to complementary DNA samples, reverse-transcribed from polyadenylated… CONTINUE READING

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