Global Gene Expression Analysis of Canine Osteosarcoma Stem Cells Reveals a Novel Role for COX-2 in Tumour Initiation

@inproceedings{Pang2014GlobalGE,
  title={Global Gene Expression Analysis of Canine Osteosarcoma Stem Cells Reveals a Novel Role for COX-2 in Tumour Initiation},
  author={Lisa Y Pang and Emma L. Gatenby and Ayako Kamida and Bruce Whitelaw and Ted R. Hupp and David John Argyle},
  booktitle={PloS one},
  year={2014}
}
Osteosarcoma is the most common primary bone tumour of both children and dogs. It is an aggressive tumour in both species with a rapid clinical course leading ultimately to metastasis. In dogs and children distant metastasis occurs in >80% of individuals treated by surgery alone. Both canine and human osteosarcoma has been shown to contain a sub-population of cancer stem cells (CSCs), which may drive tumour growth, recurrence and metastasis, suggesting that naturally occurring canine… CONTINUE READING
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