Global DNA methylation levels in white blood cells as a biomarker for hepatocellular carcinoma risk: a nested case-control study.

@article{Wu2012GlobalDM,
  title={Global DNA methylation levels in white blood cells as a biomarker for hepatocellular carcinoma risk: a nested case-control study.},
  author={Hui-Chen Wu and Qiao Wang and H C Yang and W Y Tsai and Chien-Jen Chen and Regina M. Santella},
  journal={Carcinogenesis},
  year={2012},
  volume={33 7},
  pages={1340-5}
}
Global DNA hypomethylation is associated with genomic instability and human cancer and blood DNAs collected at the time of cancer diagnosis have been used to examine the relationship between global methylation and cancer risk. To test the hypothesis that global hypomethylation is associated with increased risk of hepatocellular carcinoma (HCC), we conducted a prospective case-control study nested within a community-based cohort with 16 years of follow-up. We measured methylation levels in… CONTINUE READING

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