Global Control of Motor Neuron Topography Mediated by the Repressive Actions of a Single Hox Gene

Abstract

In the developing spinal cord, regional and combinatorial activities of Hox transcription factors are critical in controlling motor neuron fates along the rostrocaudal axis, exemplified by the precise pattern of limb innervation by more than fifty Hox-dependent motor pools. The mechanisms by which motor neuron diversity is constrained to limb levels are… (More)
DOI: 10.1016/j.neuron.2010.08.008

Topics

8 Figures and Tables

Slides referencing similar topics