Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies

@inproceedings{Munari2016Global5L,
  title={Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies},
  author={Enrico Munari and Alcides M Chaux and Ajay M. Vaghasia and Diana Taheri and Sarah Karram and Stephania Martins Bezerra and Nilda Diana Gonzalez Roibon and William Andrew Nelson and Srinivasan Thomas Yegnasubramanian and George Joppert Netto and Michael C. Haffner and Zoran Culig},
  booktitle={PloS one},
  year={2016}
}
Solid tumors are characterized by a plethora of epigenetic changes. In particular, patterns methylation of cytosines at the 5-position (5mC) in the context of CpGs are frequently altered in tumors. Recent evidence suggests that 5mC can get converted to 5-hydroxylmethylcytosine (5hmC) in an enzymatic process involving ten eleven translocation (TET) protein family members, and this process appears to be important in facilitating plasticity of cytosine methylation. Here we evaluated the global… CONTINUE READING
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