Global, in situ, site-specific analysis of protein S-sulfenylation

@article{Yang2015GlobalIS,
  title={Global, in situ, site-specific analysis of protein S-sulfenylation},
  author={Jing Yang and Vinayak Gupta and Keri A. Tallman and Ned A. Porter and Kate S. Carroll and Daniel C. Liebler},
  journal={Nature Protocols},
  year={2015},
  volume={10},
  pages={1022-1037}
}
Protein S-sulfenylation is the reversible oxidative modification of cysteine thiol groups to form cysteine S-sulfenic acids. Mapping the specific sites of protein S-sulfenylation onto complex proteomes is crucial to understanding the molecular mechanisms controlling redox signaling and regulation. This protocol describes global, in situ, site-specific analysis of protein S-sulfenylation using sulfenic acid–specific chemical probes and mass spectrometry (MS)-based proteomics. The major steps in… CONTINUE READING
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