Gln-tRNAGln formation from Glu-tRNAGln requires cooperation of an asparaginase and a Glu-tRNAGln kinase.

@article{Feng2005GlntRNAGlnFF,
  title={Gln-tRNAGln formation from Glu-tRNAGln requires cooperation of an asparaginase and a Glu-tRNAGln kinase.},
  author={Liang Feng and Kelly Ann Sheppard and Debra Tumbula-Hansen and Dieter S{\"o}ll},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 9},
  pages={8150-5}
}
Gln-tRNA(Gln) is synthesized from Glu-tRNA(Gln) in most microorganisms by a tRNA-dependent amidotransferase in a reaction requiring ATP and an amide donor such as glutamine. GatDE is a heterodimeric amidotransferase that is ubiquitous in Archaea. GatD resembles bacterial asparaginases and is expected to function in amide donor hydrolysis. We show here that Methanothermobacter thermautotrophicus GatD acts as a glutaminase but only in the presence of both Glu-tRNA(Gln) and the other subunit, GatE… CONTINUE READING

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Mechanism of a tRNA-dependent Amidotransferase

  • M. Wilcox
  • Biochemistry
  • 1969

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