GlmS and NagB Regulate Amino Sugar Metabolism in Opposing Directions and Affect Streptococcus mutans Virulence

@inproceedings{KawadaMatsuo2012GlmSAN,
  title={GlmS and NagB Regulate Amino Sugar Metabolism in Opposing Directions and Affect Streptococcus mutans Virulence},
  author={Miki Kawada-Matsuo and Yusuke Mazda and Yuichi Oogai and Mikihito Kajiya and Toshihisa Kawai and Sakuo Yamada and Shouichi Miyawaki and Takahiko Oho and Hitoshi Komatsuzawa},
  booktitle={PloS one},
  year={2012}
}
Streptococcus mutans is a cariogenic pathogen that produces an extracellular polysaccharide (glucan) from dietary sugars, which allows it to establish a reproductive niche and secrete acids that degrade tooth enamel. While two enzymes (GlmS and NagB) are known to be key factors affecting the entrance of amino sugars into glycolysis and cell wall synthesis in several other bacteria, their roles in S. mutans remain unclear. Therefore, we investigated the roles of GlmS and NagB in S. mutans sugar… CONTINUE READING

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