Gliotoxin is a potent NOTCH2 transactivation inhibitor and efficiently induces apoptosis in chronic lymphocytic leukaemia (CLL) cells.

Abstract

Chronic lymphocytic leukaemia (CLL) cells express constitutively activated NOTCH2 in a protein kinase C (PKC)- dependent manner. The transcriptional activity of NOTCH2 correlates not only with the expression of its target gene FCER2 (CD23) but is also functionally linked with CLL cell viability. In the majority of CLL cases, DNA-bound NOTCH2 complexes are… (More)
DOI: 10.1111/bjh.12183

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@article{Hubmann2013GliotoxinIA, title={Gliotoxin is a potent NOTCH2 transactivation inhibitor and efficiently induces apoptosis in chronic lymphocytic leukaemia (CLL) cells.}, author={Rainer Hubmann and Martin Hilgarth and Susanne Schnabl and Elena Ponath and Marlies Reiter and Dita Demirtas and Wolfgang Sieghart and Peter Valent and Christoph C. Zielinski and Ulrich Jaeger and Medhat Shehata}, journal={British journal of haematology}, year={2013}, volume={160 5}, pages={618-29} }