Gliotoxin effects on fungal growth: mechanisms and exploitation.

Stephen Carberry, Emer L Molloy, +4 authors Sean Doyle
Published 2012 in Fungal genetics and biology : FG & B

Abstract

Although initially investigated for its antifungal properties, little is actually known about the effect of gliotoxin on Aspergillus fumigatus and other fungi. We have observed that exposure of A. fumigatus to exogenous gliotoxin (14 μg/ml), under gliotoxin-limited growth conditions, results in significant alteration of the expression of 27 proteins (up… (More)

DOI: 10.1016/j.fgb.2012.02.003

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The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model.

Franziska Lessing, Olaf Kniemeyer, +4 authors Axel A Brakhage
Eukaryotic cell
2007

Gliotoxin effects on fungal growth: mechanisms and exploitation.

Abstract

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Citation Velocity: 10

Cited By

Redox Metabolites Signal Polymicrobial Biofilm Development via the NapA Oxidative Stress Cascade in Aspergillus

CoIN: co-inducible nitrate expression system for secondary metabolites in Aspergillus nidulans

Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus

Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus

Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity

Genetic Transformation Systems in Fungi, Volume 2

In vitro Antagonistic Activity of Candida albicans against Filamentous Fungi

Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus

A Proteomic Approach to Investigating Gene Cluster Expression and Secondary Metabolite Functionality in Aspergillus fumigatus

References

Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin.

Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus.

Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae.

The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model.

Biochemical analysis of oxidative stress in the production of aflatoxin and its precursor intermediates

CADRE: the Central Aspergillus Data REpository

A novel redox mechanism for the glutathione-dependent reversible uptake of a fungal toxin in cells.

The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain.

Effect of competition on the production and activity of secondary metabolites in Aspergillus species.

Secondary chemicals protect mould from fungivory.

Slides referencing similar topics

Gliotoxin effects on fungal growth: mechanisms and exploitation.

Abstract

Topics

8 Figures and Tables

Statistics

Citation Velocity: 10

Cited By

Redox Metabolites Signal Polymicrobial Biofilm Development via the NapA Oxidative Stress Cascade in Aspergillus

CoIN: co-inducible nitrate expression system for secondary metabolites in Aspergillus nidulans

Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus

Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus

Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity

Genetic Transformation Systems in Fungi, Volume 2

In vitro Antagonistic Activity of Candida albicans against Filamentous Fungi

Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus

A Proteomic Approach to Investigating Gene Cluster Expression and Secondary Metabolite Functionality in Aspergillus fumigatus

References

Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin.

Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus.

Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae.

The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model.

Biochemical analysis of oxidative stress in the production of aflatoxin and its precursor intermediates

CADRE: the Central Aspergillus Data REpository

A novel redox mechanism for the glutathione-dependent reversible uptake of a fungal toxin in cells.

The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain.

Effect of competition on the production and activity of secondary metabolites in Aspergillus species.

Secondary chemicals protect mould from fungivory.

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