Gliomatosis cerebri: molecular pathology and clinical course.

  title={Gliomatosis cerebri: molecular pathology and clinical course.},
  author={Ulrich Herrlinger and Joerg Felsberg and Wilhelm K{\"u}ker and Antje Bornemann and Ludwig Pla\sswilm and Christiane B. Knobbe and Herwig M. Strik and Wolfgang Wick and Richard Meyermann and Johannes Dichgans and Michael Bamberg and Guido Reifenberger and Michael Weller},
  journal={Annals of neurology},
  volume={52 4},
Gliomatosis cerebri is a rare, diffusely growing neuroepithelial tumor characterized by extensive brain infiltration involving more than two cerebral lobes. Among 13 patients with gliomatosis cerebri (median age, 46 years), biopsies showed features of diffuse astrocytoma (n = 4), oligoastrocytoma (n = 1), anaplastic astrocytoma (n = 5), anaplastic oligoastrocytoma (n = 1), or glioblastoma (n = 2). Molecular genetic investigation showed TP53 mutations in three of seven tumors and both PTEN… CONTINUE READING


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