Gliomagenesis: genetic alterations and mouse models

  title={Gliomagenesis: genetic alterations and mouse models},
  author={Eric C. Holland},
  journal={Nature Reviews Genetics},
Glioblastoma multiforme is the most malignant of the primary brain tumours and is almost always fatal. The treatment strategies for this disease have not changed appreciably for many years and most are based on a limited understanding of the biology of the disease. However, in the past decade, characteristic genetic alterations have been identified in… CONTINUE READING