Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression.

@article{Shah2005GliomaTA,
  title={Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression.},
  author={Khalid Shah and Emilie Bureau and D R Kim and Katherine Yang and Yi Tang and Ralph Weissleder and Xandra O Breakefield},
  journal={Annals of neurology},
  year={2005},
  volume={57 1},
  pages={34-41}
}
Despite many refinements in current therapeutic strategies, the overall prognosis for a patient with glioblastoma is dismal. Neural precursor cells (NPCs) are capable of tracking glioma tumors and thus could be used to deliver therapeutic molecules. We have engineered mouse NPCs to deliver a secreted form of tumor necrosis factor-related apoptosis-inducing ligand (S-TRAIL); S-TRAIL is optimized to selectively kill neoplastic cells. Furthermore, we have developed means to simultaneously monitor… CONTINUE READING
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