Glioma invasion in the central nervous system.

  title={Glioma invasion in the central nervous system.},
  author={Alf Giese and Manfred Westphal},
  volume={39 2},
  pages={235-50; discussion 250-2}
Invading glioma cells seem to follow distinct anatomic structures within the central nervous system. Tumor cell dissemination may occur along structures, such as the basement membranes of blood vessels or the glial limitans externa, that contain extracellular matrix (ECM) proteins. Frequently, invasive glioma cells are also found to migrate along myelinated fiber tracts of white matter. This behavior is most likely a consequence of using constitutive extracellular ligands expressed along the… CONTINUE READING
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