Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model.

@article{Gagliano2009GliomaastrocyteIM,
  title={Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model.},
  author={Nicoletta Gagliano and Francesco Vittorio Costa and Chiara Cossetti and Letizia Pettinari and Rosaria Bassi and M. Chiriva-Internati and E Berrobianco Cobos and Magda Gioia and Stefano Pluchino},
  journal={Oncology reports},
  year={2009},
  volume={22 6},
  pages={1349-56}
}
As the majority of gliomas arise through malignant transformation of astrocytes, we aimed at investigating the interaction between malignant glioma cells and astrocytes in a co-culture experimental model. For this purpose we analyzed the expression of genes and proteins involved in tumor promotion and invasion, such as glial fibrillary acidic protein (GFAP), matrix metalloproteinase-2 (MMP-2), tissue inhibitor of MMP-2 (TIMP-2), transforming growth factor-beta1 (TGF-beta1), secreted protein… CONTINUE READING

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