Glioma-associated endothelial cells show evidence of replicative senescence.

@article{Charalambous2007GliomaassociatedEC,
  title={Glioma-associated endothelial cells show evidence of replicative senescence.},
  author={Christiana Charalambous and Jenilyn Joyce Virrey and Adel Kardosh and Mark N Jabbour and Lubna Qazi-Abdullah and Ligaya B Pen and Raphael Zidovetzki and Axel H Sch{\"o}nthal and Thomas L. C. Chen and Florence M. Hofman},
  journal={Experimental cell research},
  year={2007},
  volume={313 6},
  pages={
          1192-202
        }
}
The innately programmed process of replicative senescence has been studied extensively with respect to cancer, but primarily from the perspective of tumor cells overcoming this stringent innate barrier and acquiring the capacity for unlimited proliferation. In this study, we focus on the potential role of replicative senescence affecting the non-transformed endothelial cells of the blood vessels within the tumor microenvironment. Based on the well-documented aberrant structural and functional… CONTINUE READING
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