Glioma Cell Invasion: Regulation of Metalloproteinase Activity by TGF-β

@article{Wick2001GliomaCI,
  title={Glioma Cell Invasion: Regulation of Metalloproteinase Activity by TGF-β},
  author={Wolfgang Wick and Michael Platten and Michael Weller},
  journal={Journal of Neuro-Oncology},
  year={2001},
  volume={53},
  pages={177-185}
}
Matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases that selectively degrade components of the extracellular matrix. MMPs are implicated in tumor cell invasion because they mediate the breakdown of the basal membrane. In addition, they seem to be important for the creation and maintenance of a microenvironment that facilitates tumor cell survival. Among the essential characteristics of human malignant gliomas are infiltrative growth, angiogenesis and suppression of… CONTINUE READING
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