Glioma Cell Death Induced by Irradiation or Alkylating Agent Chemotherapy Is Independent of the Intrinsic Ceramide Pathway

@inproceedings{Gramatzki2013GliomaCD,
  title={Glioma Cell Death Induced by Irradiation or Alkylating Agent Chemotherapy Is Independent of the Intrinsic Ceramide Pathway},
  author={Dorothee Gramatzki and Caroline Herrmann and Caroline Happold and Katrin Anne Becker and Erich Gulbins and Michael Weller and Ghazaleh Tabatabai},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND/AIMS Resistance to genotoxic therapy is a characteristic feature of glioma cells. Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and glucosylceramide synthase (GCS) catalyzes ceramide metabolism. Increased ceramide levels have been suggested to enhance chemotherapy-induced death of cancer cells. METHODS Microarray and clinical data for ASM and GCS in astrocytomas WHO grade II-IV were acquired from the Rembrandt database. Moreover, the glioblastoma database of the… CONTINUE READING
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