Glioblastomas induce T-lymphocyte death by two distinct pathways involving gangliosides and CD70.

@article{Chahlavi2005GlioblastomasIT,
  title={Glioblastomas induce T-lymphocyte death by two distinct pathways involving gangliosides and CD70.},
  author={Ali Chahlavi and Patricia A. Rayman and Amy L Richmond and K. Biswas and Renliang Zhang and Michael A. Vogelbaum and Charles S. Tannenbaum and Gene H. Barnett and James Harold Finke},
  journal={Cancer research},
  year={2005},
  volume={65 12},
  pages={5428-38}
}
Here we report that glioblastoma multiforme (GBM) mediates immunosuppression by promoting T-cell death via tumor-associated CD70 and gangliosides that act through receptor-dependent and receptor-independent pathways, respectively. GBM lines cocultured with T cells induced lymphocyte death. The GBM lines were characterized for their expression of CD70, Fas ligand (FasL), and tumor necrosis factor-alpha (TNF-alpha), and the possible participation of those molecules in T-cell killing was assessed… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 67 references

CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.

Proceedings of the National Academy of Sciences of the United States of America • 1997
View 9 Excerpts
Highly Influenced

Detection of glioma-associated gangliosides GM2, GD2, Glioblastoma Multiforme Induced T-Cell Apoptosis www.aacrjournals.org

CJ Wikstrand, P Fredman, L Svennerholm, DD. Bigner
Cancer Res • 2005
View 1 Excerpt

Effect of renal cell carcinomas on the development of type 1 T-cell responses.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2004
View 3 Excerpts

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