Glioblastomas induce T-lymphocyte death by two distinct pathways involving gangliosides and CD70.

  title={Glioblastomas induce T-lymphocyte death by two distinct pathways involving gangliosides and CD70.},
  author={Ali Chahlavi and Patricia A. Rayman and Amy L Richmond and K. Biswas and Renliang Zhang and Michael A. Vogelbaum and Charles S. Tannenbaum and Gene H. Barnett and James Harold Finke},
  journal={Cancer research},
  volume={65 12},
Here we report that glioblastoma multiforme (GBM) mediates immunosuppression by promoting T-cell death via tumor-associated CD70 and gangliosides that act through receptor-dependent and receptor-independent pathways, respectively. GBM lines cocultured with T cells induced lymphocyte death. The GBM lines were characterized for their expression of CD70, Fas ligand (FasL), and tumor necrosis factor-alpha (TNF-alpha), and the possible participation of those molecules in T-cell killing was assessed… CONTINUE READING


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