Glioblastoma-specific anticancer activity of pheophorbide a from the edible red seaweed Grateloupia elliptica.

  title={Glioblastoma-specific anticancer activity of pheophorbide a from the edible red seaweed Grateloupia elliptica.},
  author={Myounglae Cho and Gab Man Park and Su-Nam Kim and Touseef Amna and Seokjoon Lee and Woon Seob Shin},
  journal={Journal of microbiology and biotechnology},
  volume={24 3},
The chlorophyll-related compound pheophorbide a (Pa) was successively purified from an edible red seaweed, Grateloupia elliptica, using silica, octadecyl silica column chromatography and reversed phase-high-performance liquid chromatography, as well as the cell cycle inhibitory and apoptotic effects of Pa being investigated in U87MG glioblastoma cells. The Pa exhibited strong anticancer effects in the absence of direct photo-irradiation against various cancer cell lines, including U87MG, SK-OV… 

Brown Seaweed Egregia menziesii’s Cytotoxic Activity against Brain Cancer Cell Lines

Results suggest that E. menziesii’s extracts might be good candidates for cancer prevention and the development of novel chemotherapies due to its highest cytotoxicity in transformed cells compare to glia primary cultures.

A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress

The results confirm that the growth and malignancy of colon cancer cells can be decreased by marine compounds through the modification of one of the most potent resistance mechanisms present in tumor cells; this characteristic differentiates cancer cells from nontumor cells in terms of stress balance.

Evaluation of a Brown Seaweed Extract from Dictyosiphon foeniculaceus as a Potential Therapeutic Agent for the Treatment of Glioblastoma and Uveal Melanoma

The results in glioblastoma were not promising, but the anti-tumor properties in OMM-1 could make them interesting for further research concerning cancer diseases in the human eye.

Anti-Cancer Activity of Porphyran and Carrageenan from Red Seaweeds

This review attempts to review the current study of anti-cancer activity and the possible mechanisms of porphyran and carrageenan derived from red seaweeds to various cancers, and their cooperative actions with other anti- cancer chemotherapeutic agents is also discussed.

Lysophosphatidylcholines and Chlorophyll-Derived Molecules from the Diatom Cylindrotheca closterium with Anti-Inflammatory Activity

The data suggest that lysophosphatidylcholines and a breakdown product of chlorophyll, pheophorbide a, were probably responsible for the observed anti-inflammatory activity, and demonstrated the importance of proper dereplication of bioactive extracts and fractions before isolation of compounds is commenced.

Effects of Ethanol Extracts from Grateloupia elliptica, a Red Seaweed, and Its Chlorophyll Derivative on 3T3-L1 Adipocytes: Suppression of Lipid Accumulation through Downregulation of Adipogenic Protein Expression

Chlorophyll derivative from G. elliptica inhibits lipid accumulation by suppressing adipogenesis via the downregulation of adipogenic protein expressions in the differentiated adipocytes and could be utilized as a potential therapeutic agent for preventing obesity.

Ethanol extracts of Cinnamomum kanehirai Hayata leaves induce apoptosis in human hepatoma cell through caspase-3 cascade

C. kanehirai Hayata ethanol extract induced intrinsic pathway of apoptosis through caspase-3 cascade in human hepatoma HA22T/VGH and HepG2 cells, which might shed new light on hepatoma therapy.



Pheophorbide a, a major antitumor component purified from Scutellaria barbata, induces apoptosis in human hepatocellular carcinoma cells.

Mechanistic studies showed that pheophorbide a induced apoptosis in Hep3B cells, a viral-induced hepatoma cell line, but it was found to be non-toxic in normal human liver cells WRL-68 and the anti-proliferative activity and possible mechanisms of action are discussed.

Pheophorbide a based photodynamic therapy induces apoptosis via mitochondrial-mediated pathway in human uterine carcinosarcoma

It is demonstrated that using Pa in PDT (Pa-PDT) significantly inhibited the human uterine sarcoma cell line MES-SA with an IC50 value of 0.5 μM at 24 h.

Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum.

Three pheophorbide-related compounds (1-3) were isolated from the leaves and stems of Clerodendrum calamitosum and the methyl esters of 1-3 showed strongly increased cytotoxicity compared with the parent acids, Interestingly, 6 was the most active derivative among these compounds.

Pheophorbide a-Mediated Photodynamic Therapy Triggers HLA Class I-Restricted Antigen Presentation in Human Hepatocellular Carcinoma.

These findings provide the first evidence that Pa-PDT can trigger both apoptosis and cancer immunity in the tumor host.

Potential anticancer activity of young Carpinus betulus leaves.

Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells.

Anti-inflammatory activity of edible brown alga Saccharina japonica and its constituents pheophorbide a and pheophytin a in LPS-stimulated RAW 264.7 macrophage cells.

  • M. IslamIshrat Jahan Ishita J. Choi
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013

Selective cytotoxicity of marine algae extracts to several human leukemic cell lines

Extracts from 8 species of marine algae which showed selective cytotoxicity in a previous screening program, were further examined for cytotoxic spectra to five human leukemic cell lines and it was considered that a red alga, Amphiroa zonata might be suitable natural source for development of anti-cancer agents without side-effect.