Glioblastoma-specific anticancer activity of pheophorbide a from the edible red seaweed Grateloupia elliptica.

@article{Cho2014GlioblastomaspecificAA,
  title={Glioblastoma-specific anticancer activity of pheophorbide a from the edible red seaweed Grateloupia elliptica.},
  author={Myounglae Cho and Gab Man Park and Su-Nam Kim and Touseef Amna and Seokjoon Lee and Woon Seob Shin},
  journal={Journal of microbiology and biotechnology},
  year={2014},
  volume={24 3},
  pages={
          346-53
        }
}
The chlorophyll-related compound pheophorbide a (Pa) was successively purified from an edible red seaweed, Grateloupia elliptica, using silica, octadecyl silica column chromatography and reversed phase-high-performance liquid chromatography, as well as the cell cycle inhibitory and apoptotic effects of Pa being investigated in U87MG glioblastoma cells. The Pa exhibited strong anticancer effects in the absence of direct photo-irradiation against various cancer cell lines, including U87MG, SK-OV… 

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References

SHOWING 1-10 OF 35 REFERENCES

Pheophorbide a, a major antitumor component purified from Scutellaria barbata, induces apoptosis in human hepatocellular carcinoma cells.

Mechanistic studies showed that pheophorbide a induced apoptosis in Hep3B cells, a viral-induced hepatoma cell line, but it was found to be non-toxic in normal human liver cells WRL-68 and the anti-proliferative activity and possible mechanisms of action are discussed.

Pheophorbide a based photodynamic therapy induces apoptosis via mitochondrial-mediated pathway in human uterine carcinosarcoma

It is demonstrated that using Pa in PDT (Pa-PDT) significantly inhibited the human uterine sarcoma cell line MES-SA with an IC50 value of 0.5 μM at 24 h.

Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum.

Three pheophorbide-related compounds (1-3) were isolated from the leaves and stems of Clerodendrum calamitosum and the methyl esters of 1-3 showed strongly increased cytotoxicity compared with the parent acids, Interestingly, 6 was the most active derivative among these compounds.

Pheophorbide a-Mediated Photodynamic Therapy Triggers HLA Class I-Restricted Antigen Presentation in Human Hepatocellular Carcinoma.

These findings provide the first evidence that Pa-PDT can trigger both apoptosis and cancer immunity in the tumor host.

Potential anticancer activity of young Carpinus betulus leaves.

Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells.

Anti-inflammatory activity of edible brown alga Saccharina japonica and its constituents pheophorbide a and pheophytin a in LPS-stimulated RAW 264.7 macrophage cells.

  • M. IslamIshrat Jahan Ishita J. Choi
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013

Selective cytotoxicity of marine algae extracts to several human leukemic cell lines

Extracts from 8 species of marine algae which showed selective cytotoxicity in a previous screening program, were further examined for cytotoxic spectra to five human leukemic cell lines and it was considered that a red alga, Amphiroa zonata might be suitable natural source for development of anti-cancer agents without side-effect.