Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers

@inproceedings{Skog2008GlioblastomaMT,
  title={Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers},
  author={Johan K Skog and Tom Wurdinger and Sjoerd van Rijn and Dimphna H M Meijer and Laura Gainche and Miguel Sena-Esteves and William Thomas Curry and Robert S. Carter and Anna M. Krichevsky and Xandra O Breakefield},
  booktitle={Nature Cell Biology},
  year={2008}
}
Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain microvascular endothelial cells. By incorporating an mRNA for a reporter protein into these microvesicles, we demonstrate that messages delivered by microvesicles are translated by recipient cells. These microvesicles are also enriched in angiogenic proteins and stimulate tubule formation by endothelial cells. Tumour… CONTINUE READING
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