Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype.

  title={Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype.},
  author={Konrad R. Gabrusiewicz and Benjamin A. T. Rodriguez and Jun Wei and Yuuri Hashimoto and Luke M Healy and Sourindra N. Maiti and Ginu A. Thomas and Shouhao Zhou and Qianghu Wang and Ahmed Elakkad and Brandon D Liebelt and Nasser Khaled Yaghi and Ravesanker Ezhilarasan and Neal Huang and Jeffrey S. Weinberg and Sujit S. Prabhu and Ganesh Rao and Raymond A Sawaya and Lauren A. Langford and Janet M. Bruner and Gregory N Fuller and Amit Bar-Or and Wei Li and Rivka R. Colen and Michael A. Curran and Krishna P. L. Bhat and Jack P. Antel and Laurence J. N. Cooper and Erik P. Sulman and Amy Heimberger},
  journal={JCI insight},
  volume={1 2}
Glioblastomas are highly infiltrated by diverse immune cells, including microglia, macrophages, and myeloid-derived suppressor cells (MDSCs). Understanding the mechanisms by which glioblastoma-associated myeloid cells (GAMs) undergo metamorphosis into tumor-supportive cells, characterizing the heterogeneity of immune cell phenotypes within glioblastoma subtypes, and discovering new targets can help the design of new efficient immunotherapies. In this study, we performed a comprehensive battery… CONTINUE READING
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Macrophage ablation reduces M 2like populations and jeopardizes tumor growth in a MAFIAbased glioma model

  • K Gabrusiewicz
  • Neoplasia
  • 2015

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