Glioblastoma cell enrichment is critical for analysis of phosphorylated drug targets and proteomic-genomic correlations.

@article{Mueller2014GlioblastomaCE,
  title={Glioblastoma cell enrichment is critical for analysis of phosphorylated drug targets and proteomic-genomic correlations.},
  author={Claudius Mueller and Ana C deCarvalho and Tom Mikkelsen and Norman L Lehman and Valerie S. Calvert and Virginia Espina and Lance A. Liotta and Emanual F. Petricoin},
  journal={Cancer research},
  year={2014},
  volume={74 3},
  pages={818-28}
}
The quality of cancer genomic and proteomic data relies upon the quality of the clinical specimens examined. Here, we show that data derived from non-microdissected glioblastoma multiforme tumor tissue is either masked or not accurate, producing correlations between genomic and proteomic data that lead to false classifications for therapeutic stratification. We analyzed the level of 133 key signaling proteins and phosphoproteins in laser capture microdissected (LCM) primary tumors from a study… CONTINUE READING

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