Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrin.

@article{Tchaicha2011GlioblastomaAA,
  title={Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrin.},
  author={Jeremy H. Tchaicha and Steve B. Reyes and Jaekyung Shin and Mohammad G. Hossain and Frederick F. Lang and Joseph H McCarty},
  journal={Cancer research},
  year={2011},
  volume={71 20},
  pages={6371-81}
}
Glioblastoma multiforme (GBM) is a highly invasive brain tumor that develops florid microvascular proliferation and hemorrhage. However, mechanisms that favor invasion versus angiogenesis in this setting remain largely uncharacterized. Here, we show that integrin β8 is an essential regulator of both GBM-induced angiogenesis and tumor cell invasiveness. Highly angiogenic and poorly invasive tumors expressed low levels of β8 integrin, whereas highly invasive tumors with limited neovascularization… CONTINUE READING
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A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis

  • JH Tchaicha, AK Mobley, MG Hossain, KD Aldape, JH. McCarty
  • Oncogene
  • 2010
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