Glioblastoma Multiforme Therapy and Mechanisms of Resistance

  title={Glioblastoma Multiforme Therapy and Mechanisms of Resistance},
  author={Yulian P. Ramirez and Jessica Leigh Weatherbee and Richard T Wheelhouse and Alonzo H. Ross},
Glioblastoma multiforme (GBM) is a grade IV brain tumor characterized by a heterogeneous population of cells that are highly infiltrative, angiogenic and resistant to chemotherapy. The current standard of care, comprised of surgical resection followed by radiation and the chemotherapeutic agent temozolomide, only provides patients with a 12-14 month survival period post-diagnosis. Long-term survival for GBM patients remains uncommon as cells with intrinsic or acquired resistance to treatment… CONTINUE READING

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