Glioblastoma: molecular analysis and clinical implications.

  title={Glioblastoma: molecular analysis and clinical implications.},
  author={Jason T Huse and Eric C. Holland and Lisa M DeAngelis},
  journal={Annual review of medicine},
Glioblastoma, the most common malignant primary brain tumor, carries an invariably poor prognosis. Targeting underlying biological foundations of the disease will be crucial to developing more effective treatment strategies. Although increasing evidence clearly indicates that glioblastoma is a molecularly heterogeneous disorder, recent large-scale expression profiling has provided a framework for categorizing the tumor into 3 to 4 distinct subclasses, each with its own characteristic genomic… CONTINUE READING

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