Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies

@article{Agnihotri2012GlioblastomaAB,
  title={Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies},
  author={Sameer Agnihotri and Kelly E. Burrell and Amparo M Wolf and Sharzhad Jalali and Cynthia Hawkins and James T. Rutka and Gelareh Mohammed Zadeh},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
  year={2012},
  volume={61},
  pages={25-41}
}
Glioblastoma (GBM) is the most common and lethal primary brain tumor. Over the past few years tremendous genomic and proteomic characterization along with robust animal models of GBM have provided invaluable data that show that “GBM”, although histologically indistinguishable from one another, are comprised of molecularly heterogenous diseases. In addition, robust pre-clinical models and a better understanding of the core pathways disrupted in GBM are providing a renewed optimism for novel… CONTINUE READING
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