Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons

@article{Liu2013GlimepirideAA,
  title={Glimepiride attenuates A$\beta$ production via suppressing BACE1 activity in cortical neurons},
  author={Fei Liu and Yijin Wang and M. Yan and L. Zhang and Tao Pang and H. Liao},
  journal={Neuroscience Letters},
  year={2013},
  volume={557},
  pages={90-94}
}
Numerous lines of evidence suggest a strong link between diabetes mellitus and Alzheimer's disease (AD). Impaired insulin signaling and insulin resistance occur not only in diabetes but also in the brain of AD. Recent evidence has indicated that peroxisome proliferator-activated receptor γ (PPARγ) agonists thiazolidinediones (TZDs) can decrease β-amyloid peptide (Aβ) deposition, which is the core component of senile plaques in AD, but the underlying mechanisms still remain unclear. In this… Expand
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Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
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