Glibenclamide treatment recruits beta-cell subpopulation into elevated and sustained basal insulin synthetic activity.

Abstract

Use of sulfonylureas in diabetes treatment is based on their insulin-releasing effect on pancreatic beta-cells. Prolonged action is known to degranulate beta-cells, but functional consequences have not been examined at the cellular level. This study investigates influences of in vivo (48-h) and in vitro (24-h) glibenclamide treatment on the functional state… (More)

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